Structure-activity Relationships of New Aranorosin Analogs to Antifungal Activity.
نویسندگان
چکیده
منابع مشابه
Structure-activity relationships of new aranorosin analogs to antifungal activity.
prepared by stirring a mixture of 1 with the corresponding carboxylic acid (1.1 equiv.) in the presence of dicyclohexylcarbodiimide (DCC) (1.1 equiv.) and 4-dimethylaminopyridine (DMAP) (0.1 equiv.) in CH2Cl2 at room temperature for 24 hours. The crude products, obtained after usual work up, were purified by preparative TLC on silica gel (Article No. 13794, E. Merck) using CHCl3 MeOH (9:1) as t...
متن کاملStructure-activity relationships of cadeguomycin analogs.
The relationship between the activity and the chemical structure of cadeguomycin (CDM, 7-carboxy-7-deazaguanosine) was studied with six analogs of CDM. Both activities of CDM, enhancing the incorporation of [3H]thymidine in K562 cells and potentiating the cytotoxicity of cytosine arabinoside for K562 cells, were significantly augmented by the replacement of the 7-carboxyl group with cyano (CDM-...
متن کاملAntifungal activity of homoaconitate and homoisocitrate analogs.
Thirteen structural analogs of two initial intermediates of the L-α-aminoadipate pathway of L-lysine biosynthesis in fungi have been designed and synthesized, including fluoro- and epoxy-derivatives of homoaconitate and homoisocitrate. Some of the obtained compounds exhibited at milimolar range moderate enzyme inhibitory properties against homoaconitase and/or homoisocitrate dehydrogenase of Ca...
متن کاملSynthesis and structure-activity relationships of fenbufen amide analogs.
The previous discoveries of butyl fenbufen amide analogs with antitumor effects were further examined. The amide analogs with 1, 3, 4 and 8 carbons chains were prepared in 70-80% yield. Fenbufen had no cytotoxic effects at concentrations ranging from 10 to 100 μM. Methyl fenbufen amide had significant cytotoxic effects at a concentration of 100 μM. As the length of the alkyl amide side chain in...
متن کاملInsights into structure-activity relationships of somatostatin analogs containing mesitylalanine.
The non-natural amino acid mesitylalanine (2,4,6-trimethyl-L-phenylalanine; Msa) has an electron-richer and a more conformationally restricted side-chain than that of its natural phenylalanine counterpart. Taking these properties into account, we have synthesized ten somatostatin analogs containing Msa residues in different key positions to modify the intrinsic conformational flexibility of the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1998
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.51.522